Introduction: The prevalence and clinical significance of central adrenal insufficiency (CAI) in adult patients with Prader Willi Syndrome (PWS) remains unclear. Aim: To assess the prevalence of CAI in adults with PWS and to analyse the effects of replacement therapy with hydrocortisone (HCT) in patients with suspected CAI. Material and Methods: Twenty one adult patients with PWS were evaluated. Based on peak cortisol at the 30 minute of the high dose short Synacthen test (HDSST), patients were divided into three groups: CAI (central adrenal insufficiency) - peak cortisol \<500nmol/L, intermediate (partial AI) - peak cortisol ≥500 nmol/L and \<600 nmol/L and AS (adrenal sufficiency) - peak cortisol ≥ 600 nmol/L. In patients with diagnosed CAI HCT replacement treatment was initiated. Body weight, body fat percentage, signs, and symptoms of CAI were evaluated after 6 and 12 months of treatment.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
The prevalence of CAI in adult PWS patients based on HDSST.
Timeframe: At first visit (before HCT treatment).
Symptoms of CAI before hydrocortisone substitution: fatigue
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: fatigue
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: fatigue
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: loss of appetite
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: loss of appetite
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: loss of appetite
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: muscle weakness
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocortisone treatment: muscle weakness
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocortisone treatment: muscle weakness
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: myalgia
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: myalgia
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: myalgia
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: arthralgia
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: arthralgia
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: arthralgia
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: weight loss
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: weight loss
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: weight loss
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: nausea
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: nausea
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: nausea
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: vomiting
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: vomiting
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: vomiting
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: abdominal pain
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: abdominal pain
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: abdominal pain
Timeframe: After 12 month HCT treatment
BMI before hydrocortisone substitution in PWS patients with CAI
Timeframe: Before HCT treatment
BMI after 6 month hydrocortisone substitution in PWS patients with CAI
Timeframe: After 6 month HCT treatment
BMI after 12 month hydrocortisone substitution in PWS patients with CAI
Timeframe: After 12 month HCT treatment
Body fat percentage before hydrocortisone substitution in PWS patients with CAI
Timeframe: Before HCT treatment
Body fat percentage after 6 month hydrocortisone substitution in PWS patients with CAI
Timeframe: After 6 month HCT treatment
Body fat percentage after 12 month hydrocortisone substitution in PWS patients with CAI
Timeframe: After 12 month HCT treatment