Introduction: The prevalence and clinical significance of central adrenal insufficiency (CAI) in adult patients with Prader Willi Syndrome (PWS) remains unclear. Aim: To assess the prevalence of CAI in adults with PWS and to analyse the effects of replacement therapy with hydrocortisone (HCT) in patients with suspected CAI. Material and Methods: Twenty one adult patients with PWS were evaluated. Based on peak cortisol at the 30 minute of the high dose short Synacthen test (HDSST), patients were divided into three groups: CAI (central adrenal insufficiency) - peak cortisol \<500nmol/L, intermediate (partial AI) - peak cortisol ≥500 nmol/L and \<600 nmol/L and AS (adrenal sufficiency) - peak cortisol ≥ 600 nmol/L. In patients with diagnosed CAI HCT replacement treatment was initiated. Body weight, body fat percentage, signs, and symptoms of CAI were evaluated after 6 and 12 months of treatment.
Age range
18 Years – 26 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
The prevalence of CAI in adult PWS patients based on HDSST.
Timeframe: At first visit (before HCT treatment).
Symptoms of CAI before hydrocortisone substitution: fatigue
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: fatigue
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: fatigue
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: loss of appetite
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: loss of appetite
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: loss of appetite
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: muscle weakness
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocortisone treatment: muscle weakness
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocortisone treatment: muscle weakness
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: myalgia
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: myalgia
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: myalgia
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: arthralgia
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: arthralgia
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: arthralgia
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: weight loss
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: weight loss
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: weight loss
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: nausea
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: nausea
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: nausea
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: vomiting
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: vomiting
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: vomiting
Timeframe: After 12 month HCT treatment
Symptoms of CAI before hydrocortisone substitution: abdominal pain
Timeframe: Before HCT treatment
Symptoms of CAI after 6 month hydrocorisone treatment: abdominal pain
Timeframe: After 6 month HCT treatment
Symptoms of CAI after 12 month hydrocorisone treatment: abdominal pain
Timeframe: After 12 month HCT treatment
BMI before hydrocortisone substitution in PWS patients with CAI
Timeframe: Before HCT treatment
BMI after 6 month hydrocortisone substitution in PWS patients with CAI
Timeframe: After 6 month HCT treatment
BMI after 12 month hydrocortisone substitution in PWS patients with CAI
Timeframe: After 12 month HCT treatment
Body fat percentage before hydrocortisone substitution in PWS patients with CAI
Timeframe: Before HCT treatment
Body fat percentage after 6 month hydrocortisone substitution in PWS patients with CAI
Timeframe: After 6 month HCT treatment
Body fat percentage after 12 month hydrocortisone substitution in PWS patients with CAI
Timeframe: After 12 month HCT treatment