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A Validation Study of Nitroglycerin Induced Acute Drop of Pd/Pa (NTG-Pd/Pa) in Clinical Practice

Taiwan100 participantsStarted 2021-01-02

Plain-language summary

Hyperemia with adenosine was an elemental process in FFR examination. Adenosine injection will induce some discomfort, and increase cost expenditure. Nitroglycerine will induce an acute drop of Pd/Pa, and this lowest Pd/Pa was determined as NTG-Pd/Pa. NTG-Pd/Pa has a linear relationship with FFR value and has a good diagnostic accuracy to predict FFR≤0.80 in our recent study. There is only one prospective study report on the relationship between NTG-Pd/Pa and FFR. In this study, we aim to evaluate the safety of NTG-Pd/Pa, the repeatability and dose-response of this novel index. Furthermore, we will investigate the diagnostic accuracy of NTG-Pd/Pa, with FFR≤0.8 and Resting full-cycle ratio≤0.89 as ischemic threshold respectively.

Who can participate

Age range21 Years

SexALL

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Inclusion Criteria: * Eligible for FFR examination Exclusion Criteria: * Hypersensitivity to adenosine or nitroglycerine * Severe Valvular aortic stenosis * Resting heart rate less than 50 beats per minutes * Systolic blood pressure less than 100 mmHg or diastolic blood pressure less than 40 mmHg * exposure to PDE-5 inhibitors within 48 hours. * Recent intracranial hemorrhage or brain injury

What they're measuring

The repeatability and dose response of NTG-Pd/Pa

Timeframe: 10 minutes

Trial details

NCT IDNCT04700397

SponsorNational Taiwan University Hospital Hsin-Chu Branch

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-02-29

Contact for this trial

Chien-Boon Jong, MD

+88635322140 jgboon0407@gmail.com

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