Development of Specific Diagnostic Tools for Cardiac Insufficiency With Preserved Ejection Fraction

Inclusion Criteria group 1 (ejection fraction ≥ 50%) : * Age \> or = 65, * heart failure (NT-proBNP ≥ 450 pg/mL during hospitalization or follow-up) * echocardiography showing an ejection fraction ≥ 50%, * patients already hospitalized and followed in cardiology consultation, * patients agreeing to sign informed consent, * patient affiliated to french health care system. Inclusion Criteria group 2 (ejection fraction \< 50%) : * Age \> or = 65, * heart failure (NT-proBNP ≥ 450 pg/mL during hospitalization or follow-up) * echocardiography showing an ejection fraction \< 50%, * patients already hospitalized and followed in cardiology consultation, * patients agreeing to sign informed consent, * patient affiliated to french health care system. Inclusion Criteria group 3 (without heart failure) : * Age \> or = 65, * patients already hospitalized and followed in cardiology consultation for one of the following pathology : stable coronaropathy without heart failure, arterial hypertension without heart failure, auricular fibrilation without heart failure * patients agreeing to sign informed consent, * patient affiliated to french health care system. Exclusion Criteria for all groups: * Hemodynamic instability (cardiogenic shock), * any condition leading to a prognosis of less than 7 days, * Known hepatocellular insufficiency, or known hepatic cirrhosis * ASAT / ALAT\> 10N excluding cardiac cause * Any conditions that may put the patient at risk or increase the risk of non-comp…