CompletedPhase 4

Reduction of Progesterone Elevation at Trigger in POR After Long Acting COS Compared With Daily COS: a Prospective Randomized Trial

Italy110 participantsStarted 2022-02-22

Plain-language summary

The overarching objective of this research is to generate clinical evidence to argue the benefits of long acting stimulation protocol compared to the daily stimulation protocol in poor ovarian responder bologna' criteria patients after controlled ovarian stimulation. Reduction in the proportion of subjects with progesterone \> 1.1 ng/ml on the day of triggering (day + 13) in the experimental group compared to the control group is expected.

Who can participate

Age range25 Years – 42 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Indication to IVF treatment * Normal BMI (18.5-24.9 kg/m2) * AMH level \< 1.1 ng/ml and/or AFC \< 5 follicles and/or \< 3 oo-cytes retrieved in previous cycle * Regular menstrual cycles * Signed informed consent Exclusion Criteria: * Freeze all cycles for abnormal bleeding * PCOS * History of untreated autoimmune * Endocrine or metabolic disorders * Ovarian cystectomy or oophorectomy * FSH ≥ 20 lU/L

What they're measuring

Premature progesterone elevation

Timeframe: day 12

Trial details

NCT IDNCT04695483

SponsorIRCCS San Raffaele

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-01-19

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