CompletedNot Applicable

Aerobic Group Exercise for Adolescents With Depression

Sweden14 participantsStarted 2021-03-08

Plain-language summary

The aim is to evaluate aerobic group exercise versus leisure group activities in adolescents with mild to moderate depression. Primary outcome is Children's Depression Rating Scale - Revised (CDRS-R). Secondary outcomes are Clinical Global Impressions - Severity and Improvement scales (CGI), self-reported Quick Inventory of Depression Symptomatology (QIDS- A17-SR), the self-reported Outcome Rating Scale (ORS), clinician rated Children Global Assessment Scale (C-GAS), aerobic capacity (VO2max), muscular strength, body, Body Mass Index (BMI), presence or activity of selected biological markers of neuroprotection and neuroinflammation in blood samples and a cost evaluation rated by parents with Trimbos/iMTA questionnaire for Costs associated with Psychiatric Illness - Child version (Tic-P). Further objectives are qualitative interviews to explore adolescents' experiences of the intervention as well as how their health and lifestyle are influenced and a validation of QIDS- A17-C and QIDS- A17-SR versus CDRS-R will be performed.

Who can participate

Age range13 Years – 17 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * DSM-5 mild to moderate depression * Who have received evaluation and basic psychosocial interventions for 4-8 weeks (minimum four visits) without response, i.e. not achieved improvement by at least 50 % as assessed from clinical records Exclusion Criteria: * Eating disorder * High risk for suicide * Intellectual disability * Actual physical activity the last four weeks meeting the level for sustained health by American College of Sports Medicine, i.e. at least 150 min per week of moderate intensity or 75 min per week of high intensity38 * Adjustment of antidepressant medication within the last four weeks or stimulants the last two weeks * Chronic somatic illness precluding exercise * In need of interpreter * Social circumstances interfering with a regular exercise schedule * Concomitant psychotherapy

What they're measuring

Change in Children's Depression Rating Scale- Revised (CDRS-R)

Timeframe: After intervention (at 13 weeks) and at follow-up (at 52 weeks)

Trial details

NCT IDNCT04695145

SponsorLund University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-06-18