Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans (NCT04691986) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans
United States74 participantsStarted 2023-09-01
Plain-language summary
Frailty is an age-associated clinical condition of poor physiological reserve that increases risks for falls, hospitalization and mortality. Nicotinamide adenine dinucleotide (NAD) is a critical co-factor needed for many cellular processes. The natural levels of NAD decline aging and this has been linked to physical performance decline in animals. Human trials have demonstrated that nicotinamide riboside (NR), a form of vitamin B3, is safe and effectively increases NAD+ levels. In animal studies, NR improves treadmill performance and muscle quality. Here the investigators propose a double-blind randomized control trial to assess the benefits of NR supplementation on human muscle function and physiology. The investigators anticipate the research findings will support the use of this nutritional supplement to improve the health of Veterans during aging.
Who can participate
Age range
65 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Ages 65-85
* Male or female
* Any race
* Ability to use an exercise bike
* Medically cleared for muscle biopsy
Exclusion Criteria:
* Severe Co-morbidity
* examples include, but not limited to:
* congestive heart failure class equal to or above III
* chronic obstructive pulmonary disorder (COPD) gold stage IV
* chronic kidney disease equal to or above stage
* A VA-SLUMS cognitive screen score of less than or equal to 20
* Body mass index greater than or equal to 40
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Sub-maximal oxygen uptake test (VO2max)
Timeframe: Change from baseline to endpoint at 12 weeks
2
Muscle strength
Timeframe: Change from baseline to endpoint at 12 weeks
3
Gait speed
Timeframe: Change from baseline to endpoint at 12 weeks