Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders

Inclusion Criteria: * All participants will be over the age of 21 * Have symptoms suggestive of a neurodegenerative and/or related disorder Exclusion Criteria: * Participants will be excluded if they have any concurrent illnesses that could account for all of their symptoms, such as traumatic brain injury, encephalitis, strokes or developmental syndromes * Women that are pregnant or post-partum and breast-feeding will be excluded * Participants will be excluded if they have any of the following genetic conditions which can increase the chance of cancer: Cowden disease, Lynch syndrome, Hypogammaglobulinemia, Wiskott-Aldrich syndrome and Down's syndrome * Participants will be excluded if MRI is contraindicated (metal in head, cardiac pace maker, etc), if there is severe claustrophobia, if there are conditions that may confound brain imaging studies (e.g. structural abnormalities, including subdural hematoma, intracranial neoplasm or large cortical infarcts) * Participants will be excluded if they are medically unstable or are on medications that might affect brain structure or metabolism (e.g. chemotherapy)