The primary objective of this project is to extensively characterize the endotypes of pre-schoolers (0 to 6 years) and school-age children (6 to 12 years) with SA using an integrated approach, combining a description of their phenotype (asthma symptoms, atopy, and lung function) associated with histological (airway inflammation and remodelling), immune (innate and adaptive immunity), metabolomics, and microbiota analyses. This goal shall be achieved by an unsupervised in-depth analysis of patients requiring bronchial endoscopy, with bronchial alveolar lavage (BAL) and bronchial biopsy, as part of their clinical assessment.
Age range
12 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Description of the environment and smoke exposure
Timeframe: 1 day
Description of family atopy status
Timeframe: 1 day
Description of Demographics
Timeframe: 1 day
Description of Asthma history in the past year
Timeframe: 1 day
Description of Lung function
Timeframe: 1 day
Description of Asthma therapy
Timeframe: 1 day
Description of Airway remodeling
Timeframe: 1 day
Description of inflammatory and histological features in bronchoalveolar lavages (BAL)
Timeframe: 1 day
Description of inflammatory and histological features in bronchial mucosa
Timeframe: 1 day
Bronchial mucosa analysis
Timeframe: 1 day
BAL analysis
Timeframe: 1 day
Blood analysis
Timeframe: 1 day
Metabolomic signature
Timeframe: 1 day
Microbiota analysis
Timeframe: 1 day