RecruitingNot Applicable

A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy

United States, Netherlands1,000 participantsStarted 2021-11-24

Plain-language summary

The purpose of this study is to determine the efficacy and safety of a personalised surveillance and intervention protocol for patients with familial adenomatous polyposis (FAP) that have undergone (procto)colectomy.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP) * Have undergone prophylactic (procto)colectomy with IRA/ISA or IPAA * Age 18 years or older Exclusion Criteria: * Not able to remove all polyps with an indication for removal during (multiple) clearing endoscopies * Cancer at baseline endoscopy * Need for surgery

What they're measuring

Advanced neoplasia

Timeframe: Up to 5 years

Trial details

NCT IDNCT04678011

SponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-11

View on ClinicalTrials.gov More Familial Adenomatous Polyposis trials