Integrated Outpatient Treatment of Opioid Use Disorder and Severe Injection Related Infections

Inclusion Criteria: * have opioid use disorder * have a severe injection related infection requiring antibiotics * willing to accept buprenorphine treatment * anticipated to be discharged home * require IV antibiotic therapy Exclusion Criteria: * stroke or cerebral mycotic aneurysms preventing aortic or mitral valve surgery * fungal valve IE * requiring in-patient rehabilitation * current pregnancy * hypersensitivity or allergy to buprenorphine * class III or IV heart failure * end-stage liver or renal disease * any condition that may prevent the volunteer from safely participating in the study * self-report of desire to inject into the PICC line * pending legal action that could interfere with study participation * unsafe or unstable environment precluding safe administration of IV antibiotics * living more than a 60 minute drive outside of Lexington, KY