RecruitingNot Applicable

iCorMicA - Stratified Medicine in Angina

Ireland, Netherlands, Poland1,500 participantsStarted 2020-12-30

Plain-language summary

The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age ≥18 years.
✓. A clinical plan for invasive coronary angiography.
✓. Symptoms of angina (typical or atypical) according to the Rose- and/or Seattle Angina questionnaires.
✓. Able to comply with study procedures.
✓. Able to provide informed consent.

Exclusion criteria

✕. A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure).
✕. History of coronary artery bypass surgery.
✕. Presence of obstructive disease evident in a main coronary artery (diameter \>2.5 mm), i.e. a coronary stenosis \>50% and/or a fractional flow reserve (FFR) ≤0.80\*.
✕. Logistical reason\*. \*These patients will enter a follow-up registry.

What they're measuring

Seattle Angina Questionnaire (SAQ) Summary Score

Timeframe: 12 months

Trial details

NCT IDNCT04674449

SponsorNHS Greater Glasgow and Clyde

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06-30

Contact for this trial

Colin Berry, MBChB, PhD

+44 141 330 3325 colin.berry@glasgow.ac.uk

View on ClinicalTrials.gov More Microvascular Angina trials