Fitness for Brain Optimization for Late-Life Depression (NCT04670510) | Clinical Trial Compass
CompletedNot Applicable
Fitness for Brain Optimization for Late-Life Depression
United States46 participantsStarted 2021-08-04
Plain-language summary
Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD). In this study, investigators will examine systemic neural and cognitive benefits of aerobic exercise training in older adults with remitted LLD. This will generate preliminary data regarding neural targets of aerobic exercise training that may translate to cognitive benefits in those with rLLD, a population who remains at high risk for dementia despite successful treatment of depression.
Who can participate
Age range60 Years
SexALL
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Inclusion criteria
✓. Men and women 60+ years
✓. Major Depressive Episode in older adulthood (since age 55)
✓. Current level of depressive symptoms does not meet criteria for a Major Depressive Episode
✓. Ambulatory without pain or the assistance of walking devices
✓. Able to speak and read English
✓. Exercise level of \<100 minutes per week on average
✓. Medical clearance by primary care physician (PCP)
✓. Living in community for duration of the study
Exclusion criteria
✕. Current diagnosis of a Major Depressive Episode
✕. Psychosis
✕. Significant suicide risk (i.e., current, active suicidal ideation with a plan)
What they're measuring
1
Change from baseline in Cardiovascular Fitness at 6 months
Timeframe: Baseline and 6-months
2
Changes from baseline in Brain Structure and Function at 6 months
Timeframe: Baseline and 6-months
3
Changes from baseline in depressive symptoms at 6 months
Timeframe: Baseline and 6-months
4
Depressive Symptoms
Timeframe: Continuously up to every 6-weeks for 6 months
5
Change from baseline in Cognitive Function at 6 months