Fitness for Brain Optimization for Late-Life Depression (NCT04670510) | Clinical Trial Compass
CompletedNot Applicable
Fitness for Brain Optimization for Late-Life Depression
United States46 participantsStarted 2021-08-04
Plain-language summary
Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD). In this study, investigators will examine systemic neural and cognitive benefits of aerobic exercise training in older adults with remitted LLD. This will generate preliminary data regarding neural targets of aerobic exercise training that may translate to cognitive benefits in those with rLLD, a population who remains at high risk for dementia despite successful treatment of depression.
Who can participate
Age range
60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Men and women 60+ years
. Major Depressive Episode in older adulthood (since age 55)
. Current level of depressive symptoms does not meet criteria for a Major Depressive Episode
. Ambulatory without pain or the assistance of walking devices
. Able to speak and read English
. Exercise level of \<100 minutes per week on average
. Medical clearance by primary care physician (PCP)
. Living in community for duration of the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change from baseline in Cardiovascular Fitness at 6 months
Timeframe: Baseline and 6-months
2
Changes from baseline in Brain Structure and Function at 6 months
Timeframe: Baseline and 6-months
3
Changes from baseline in depressive symptoms at 6 months
Timeframe: Baseline and 6-months
4
Depressive Symptoms
Timeframe: Continuously up to every 6-weeks for 6 months
5
Change from baseline in Cognitive Function at 6 months