Effect of Vitamin K Supplementation on Circulating Levels of Osteocalcin on the Bone Metabolism and Aging

Inclusion Criteria Inclusion criteria for the group "Patients with osteoporosis": * Age ≥ 65 years * Serum levels of 25OHD\> 30 ng / ml (as per clinical practice) * Adequate calcium intake (assessed by questionnaire) * Diagnosis of severe primary osteoporosis * Criteria for the prescription and reimbursement of treatment with Teriparatide 20 microg / day subcutaneous according to the Italian Agency of Pharma (AIFA) 79 * Patient suitable for treatment with MK-7 * Informed consent freely acquired before the person was enrolled Inclusion criteria for the group "subjects without osteoporosis": * Age ≥ 65 years * Serum levels of 25OHD\> 30 ng / ml (as per clinical practice) * Adequate calcium intake (assessed by questionnaire). * Informed consent freely acquired before the person was enrolled Exclusion Criteria: Exclusion criteria for the group of "Patients with osteoporosis": * causes of secondary osteoporosis: current glucocorticoid therapy, active and uncontrolled rheumatic diseases, endogenous hypercortisolism, uncontrolled hyperthyroidism or hypothyroidism (except known hypothyroidism well compensated with L-thyroxine), chronic renal failure (IRC) with glomerular filtration rate (GFR) \<30 ml / min, multiple myeloma, liver failure (chronic liver disease of CHILD class B and C), heart failure (New York Heart Association, also said NHYA) NHYA\> 2, active neoplasms, type 1 and type 2 diabetes mellitus * ongoing therapies: glucocorticoids, antiepileptics, aromatase inhibit…