A Human Controlled Infection Study with Neisseria Lactamica in Malian Adults

Inclusion Criteria: * Healthy adults aged 18 to 45 years inclusive on the day of enrolment residing outside the demographic surveillance area * Able and willing (in the investigator's opinion) to understand and comply with all study requirements including availability for all study follow up visits * Provide written informed consent to participate in the trial * For females only, all the following: * willingness to practice continuous effective contraception at least until the Day 28 visit is complete * negative urine pregnancy test on the screening day * negative urine pregnancy test on inoculation day Exclusion Criteria: Eligibility Minimum Age: 18 Years Maximum Age: 45 Years Sex: All Gender Based: No Accepts Healthy Volunteers: Yes Criteria: Inclusion Criteria: * Healthy adults aged 18 to 45 years inclusive on the day of enrolment residing outside the demographic surveillance area * Able and willing (in the investigator's opinion) to understand and comply with all study requirements including availability for all study follow up visits * Provide written informed consent to participate in the trial * For females only, all the following: * willingness to practice continuous effective contraception at least until the Day 28 visit is complete * negative urine pregnancy test on the screening day * negative urine pregnancy test on inoculation day Exclusion Criteria: * N. lactamica detected on throat swab taken at the screening visit * Individuals who have an ongoing acute…