Every year, thousands of Canadians receive life-saving, cost-effective organ transplants, while thousands more still wait or die because not enough organs are available. Patients with non-recoverable illnesses, who are undergoing withdrawal of life sustaining measures, can donate their organs when they die by a process called donation after circulatory determined death (DCD). However, over 30% of all DCD attempts are unsuccessful because patients do not die within the time frame required for healthy organ retrieval and prolonged exposure to low oxygen during the dying process renders organs unsuitable for transplantation. Predicting successful DCD is difficult and leads to uncertainty in the clinical community. To address this issue, the investigators have developed a clinical decision support tool called Donation Advisor (DA) that will assist the healthcare team in identifying successful DCD donors and will provide an improved assessment of the health of their organs. The investigators are ready to implement DA and evaluate its impact in 7 hospitals in Ontario. The investigators believe use of DA will reduce unsuccessful DCD attempts, enhance family experience of donation, optimize system costs, and improve transplant outcomes
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See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Waveform collection from the bedside monitor
Timeframe: From date and time of enrollment until the date and time of declaration of death, assessed up to 6 hours post withdrawal of life sustaining measures
Systemic Ischemia
Timeframe: From the date and time of withdrawal of life sustaining measures until the date and time of declaration of death, assessed up to 6 hours
Efficacy of DCD outcome prediction by the Donation Advisor (DA) Tool
Timeframe: From the date and time of withdrawal of life sustaining measures until the date and time of declaration of death, assessed up to 6 hours
Donation Advisor (DA) Tool Report
Timeframe: From the date and time the Research Coordinator initiates the report to the date and time the report displays, assessed up to 1 week
Enduser feedback on the Donation Advisor Tool Usability and Feasibility
Timeframe: Up to 1 week post declaration of death following withdrawal of life sustaining measures
Success of Organ Transplantations
Timeframe: at 28 days from organ transplantation or hospital discharge if sooner than 28 days