Human Challenge With Live-attenuated Rotavirus to Assess Next-generation Rotavirus Vaccines in Africa

Inclusion Criteria: * Healthy infants as established by medical history and physical examination. * Infants will be 6-10 weeks old at time of enrollment * parents plan to remain in the area for the duration of the study. * Parent/guardian understands the study procedures and willing to provide informed consent to participate in the study Exclusion Criteria: * Acutely unwell * Infant or infant's mother has syndromic or documented evidence of being immunocompromised (independent of HIV status) * Known allergy to any vaccine component * Previously received rotavirus vaccine * Received immunosuppressive medication * Major congenital or genetic abnormality * Any condition in the parents/infant that, in the judgment of the investigator, would interfere with or serves as a contraindication to protocol adherence or a participant's parents' ability to give informed consent. * Participant's parents not available or willing to accept active follow-up by the study staff