Functional and Neuroprotective Effects of Restoring Lower Limb Sensation After Diabetic Peripheral Neuropathy

Inclusion Criteria: * Chronic, medically stable lower limb amputation due to diabetes or insensate foot due to Diabetic peripheral neuropathy * Being ambulatory and ability to stand or walk with prosthesis or orthosis * Viable target nerves in the lower extremity as determined by standard-of-care clinical tests of nerve conduction, response to stimulation, sensory evoked potentials (SEP) and the like * Good skin integrity and personal hygiene * Absence of autoimmune deficiencies, seizure disorders or cardiac abnormalities contraindicating stimulation * Sufficient social support and personal ability to tolerate study procedures and comply with follow-up schedule Exclusion Criteria: * Active pressure ulcers or chronic skin ulcerations * Uncontrolled diabetes with HbA1c greater than or equal to 69 mmol/mol (8.5%) * Significant vascular disease * Significant history of poor wound healing * Significant history of uncontrolled infections * Active infection * Significant pain in the foot, residual or phantom limb * Pregnancy * Inability to speak English: The study design requires the subject to communicate and describe the elicited sensations in their lower limb * History of vestibular or movement disorders that would compromise balance or walking * Class II or III obesity (Body Mass Index \> 35) * Uncontrolled depression, psychoses or cognitive impairments. Subjects with unstable mental illness or severe cognitive impairments may be unable to comply with a long term study schedu…