Preliminary Efficacy Analysis of Cheng's Giraffe Reconstruction After Proximal Gastrectomy (NCT04657848) | Clinical Trial Compass
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Preliminary Efficacy Analysis of Cheng's Giraffe Reconstruction After Proximal Gastrectomy
China100 participantsStarted 2020-06-01
Plain-language summary
In the past years, the adenocarcinoma of the esophagogastric junction (AEG) has been increasing obviously in China. It may be caused by the reason of increased body weight, alcohol consumption, gastroesophageal reflux disease and premalignant. In western countries, the 5-year rate of advanced AEG was less than 30%, it was the same in China. There was significant difference in epidemiology, pathogenic mechanism, biological characteristics and prognosis between AEG and antrum tumors, so AEG was regarded as a kind of independent disease. Up till now, the scope of lymph node dissected, the selection of operation approach, the resection range and the digestive tract reconstruction for the treatment of AEG were in dispute, especially in the reconstruction of digestive tract after operation. The purpose of this study is to investigate the efficacy and safety of the proximal gastrectomy combined with Giraffe anastomosis for early adenocarcinoma of esophagogastric junction.
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion criteria
✓. Preoperative endoscopy and biopsy confirmed adenocarcinoma of esophagogastric junction, and predictively feasible of transabdominal proximal gastrectomy.
✓. Early gastric cancer, of preoperative staging AJCC 8th Edition cT1N0M0 and not suitable for endoscopic resection;
✓. Completion of abdominal CT scan and ultrasound endoscopy
✓. Age：18 to 70 years ;
✓. Karnofsky score ≥ 70
✓. With good compliance and informed consent required.
Exclusion criteria
✕. Pregnancy, breast-feeding women.
✕. The existence of the peripheral nervous system disorders or significant neurological disorders and a history of central nervous system disorders.
✕. Severity mental diseases;
✕. Patients with other severe complications cannot tolerate surgery: such as severe heart and lung diseases, heart function below clinical stage 2, uncontrollable hypertension, pulmonary infection, moderate to severe COPD, chronic bronchitis, severe diabetes and / or renal insufficiency, severe hepatitis and / or function below the rank of CHILD B grade, and severe malnutrition, etc.