UnknownNot Applicable

Effect of Anesthesia on Expression of Programmed Death-1 and Programmed Death-1 Ligand in Breast Cancer

Egypt20 participantsStarted 2017-01

Plain-language summary

Surgery is first-line treatment for solid tumors. However, surgical trauma-induced physiologic stress has been demonstrated to facilitate metastasis and recurrence in different types of cancer. It has been reported that the PD-1/PD-L1 pathway could be activated by surgical stress. Hence, we instigate the effect of anesthetic technique on expression of PD1 and PD1 ligand.

Who can participate

Age range18 Years – 65 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients scheduled for breast cancer surgery Exclusion Criteria: * compromised immune function (such as infection with the human immunodeficiency virus, immunodeficiency, or treatment with corticosteroids, immunosuppressive drugs, or chemotherapy) * ASA \> III * age\> 70 years old. * patients refusal to the procedure. * Infection of the skin at or near site of needle puncture. * Coagulopathy . * Drug hypersensitivity or allergy to the studied drugs. * Central or peripheral neuropthy . * Pre-operative opoid consumption ( within 24 hours preoperative ) * Anomalies of the vertebral column .

What they're measuring

change in level of PD1 and PD1 ligand postoperatively

Timeframe: preoerative (day-0),1st day, and 3 rd day after surgery

Trial details

NCT IDNCT04657237

SponsorAssiut University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-09

Contact for this trial

shereen M kamal, assocate professor

01006279209 sheridouh79@yahoo.com

View on ClinicalTrials.gov More Programmed Cell Death 1 trials