CompletedNot Applicable

Hyperbaric Oxygen Therapy Initiation Time in Acute Carbon Monoxide Poisoning

South Korea706 participantsStarted 2020-09-01

Plain-language summary

Hyperbaric oxygen therapy (HBO2) is recommended for symptomatic patients within 24 h of carbon monoxide (CO) poisoning. However, previous major studies found significantly better outcomes with HBO2 in patients treated within 6 h. Currently, there is no consensus on a CO poisoning-to-HBO2 interval that would not be beneficial. Therefore, the investigators aimed to evaluate the difference in therapeutic effect depending on the poisoning-to-HBO2 interval after CO exposure in patients with acute CO poisoning who received HBO2 within 24 h. The investigators compared the neurocognitive outcomes of patients according to HBO2 time intervals based on the outcomes of patients treated within 6 h (control group) with propensity score matching using the CO poisoning registry of our hospital.

Who can participate

Age range

16 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Exclusion criteria

. Not treated with HBO2
. \< 16 years old
. Non-acute CO poisoning
. Received HBO2 more than 24 h after poisoning
. A history of previous stroke or neurocognitive diseases
. Did not undergo follow-up until 6 months
. Received specific treatment other than HBO2, such as therapeutic hypothermia
. A history of previous CO exposure

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Frequency of poor global deterioration scale (GDS) at 1 month after CO exposure in the overall matched cohort

Timeframe: At 1 month after CO exposure

Frequency of poor GDS at 6 months after CO exposure in the overall matched cohort

Timeframe: At 6 months after CO exposure

Trial details

NCT IDNCT04656912

SponsorWonju Severance Christian Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-10-30

View on ClinicalTrials.gov More Hyperbaric Oxygenation trials