Active — Not RecruitingNot Applicable

Brain Stimulation for Improving Cognition in Chronic Stroke (NEPTUNE)

United States20 participantsStarted 2021-01-14

Plain-language summary

Few treatments are available for post-stroke rehabilitation. The current study aims to develop a novel, short-term, high-dose repetitive transcranial magnetic stimulation (rTMS) based intervention to improve post-stroke cognitive problems. This study will test the safety as well as changes in cognitive function and brain activation with the administration of an accelerated rTMS protocol in chronic stroke.

Who can participate

Age range40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Have right hemisphere ischemic or hemorrhagic stroke within last 6 months chronicity * Able to perform given cognitive tasks * No metal implanted in the body * A negative urine pregnancy test, if female subject of childbearing potential. Exclusion Criteria: * Primary intracerebral hematoma or subarachnoid hemorrhage * Bi-hemispheric ischemic strokes * Other concomitant neurological disorders affecting motor or cognitive function * History of seizure disorder * Preexisting scalp lesion or wound or bone defect or hemicraniectomy * Substance use disorder * Psychotic disorders * Claustrophobia

What they're measuring

Incidence of Treatment-Emergent Adverse Events and Side Effects as assessed by iTBS Review of Systems

Timeframe: Approximately 6 months.

Assess feasibility, of an accelerated protocol of rTMS in stroke patients looking at retention and using an rTMS a credibility questionnaire pre/post treatment.

Timeframe: Approximately 6 months.

Demonstrate acceptability of an accelerated protocol of rTMS in stroke patients using an acceptability of rTMS questionnaire.

Timeframe: Approximately 6 months.

Trial details

NCT IDNCT04655963

SponsorMedical University of South Carolina

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-05-15

View on ClinicalTrials.gov More Chronic Stroke trials

Plain-language summary

Who can participate

Age range40 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Incidence of Treatment-Emergent Adverse Events and Side Effects as assessed by iTBS Review of Systems

Timeframe: Approximately 6 months.

Assess feasibility, of an accelerated protocol of rTMS in stroke patients looking at retention and using an rTMS a credibility questionnaire pre/post treatment.

Timeframe: Approximately 6 months.

Demonstrate acceptability of an accelerated protocol of rTMS in stroke patients using an acceptability of rTMS questionnaire.

Timeframe: Approximately 6 months.