Integrated Care of Co-morbidities vs Standard Care After AHRF in the Intensive Care Unit (NCT04650412) | Clinical Trial Compass
TerminatedNot Applicable
Integrated Care of Co-morbidities vs Standard Care After AHRF in the Intensive Care Unit
Stopped: delayed recruitment and lack of refinancing
France, Switzerland188 participantsStarted 2018-05-28
Plain-language summary
The study will assess the potential benefit of implementing a complex bundle of interventions to treat important - often unrecognized - comorbidities in patients surviving an episode of Acute Hypercapnic Respiratory Failure (AHRF). This study will also provide a comparative analysis of the costs and health consequences of two alternative strategies to inform decision making about healthcare. All interventions are individually evidence-based and seem sound to hypothesize that implementing such interventions might improve patient's outcome and reduce the financial burder of repeated hospitalization in AHRF survivors.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Consent form signed
* Acute hypercapnic respiratory failure defined as PaCO2 \> 6.3 kPa requiring invasive or non-invasive mechanical ventilation in the ICU
Exclusion Criteria:
* Age \< 18 years old
* Known or suspected neuromuscular diseases
* Pregnancy
* Iatrogenic respiratory failure (i.e. drug overdose, AHRF after starting opiates or increasing opiates dose)
* Life expectancy \< 3 months
* Confusion or major psychiatric illness
* Patient unable to be weaned from NIV
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial was terminated before completing — do you know why it ended early, and does that affect what we can learn from its results about managing acute hypercapnic respiratory failure?
2The trial was comparing integrated care of co-morbidities versus standard care after a serious breathing crisis — based on what was found before it stopped, is there any evidence that a more integrated follow-up approach might reduce the risk of being readmitted to hospital?
3Since this study focused on hospital readmission as its main goal, what does my own care team currently do after a hospitalization for acute hypercapnic respiratory failure to help prevent me from ending up back in the ICU?
4Because the trial was terminated, the data may be incomplete — are there other completed studies or established care pathways for hypercapnic respiratory failure that you'd recommend we look at instead?
5Given that this trial looked at managing multiple co-morbidities together after a respiratory crisis, do you think my current treatment plan is addressing all the underlying conditions that might be contributing to my breathing problems?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.