Safety and Outcomes Associated With Continuous Versus Intermittent Infusion Vancomycin

Inclusion Criteria: * Adult patients at least 18 years of age * Receiving Wake Forest Baptist Health Outpatient parenteral antimicrobial therapy (OPAT) services * Will receive vancomycin therapy from Wake Forest Baptist Health Specialty Home Infusion Pharmacy * Planned therapy with vancomycin in the outpatient setting for at least 2 weeks in duration * Prescribed vancomycin with a frequency of either every 12 hours or every 8 hours dosing at the time of enrollment Exclusion Criteria: * Presence of diseases or conditions known to affect the pharmacokinetics of vancomycin: Pregnancy/Ascites/Burn injury/Cystic fibrosis /Weight greater-than or equal-to 150 kg * Pre-existing leukopenia: White Blood Cell (WBC) \< 4,000 x 103 cells/µL