UnknownEarly Phase 1

Hemodynamic Stability of Dexmedetomidine in Hypertensive Patients Undergoing Laparoscopic Cholecystectomy

Pakistan44 participantsStarted 2020-12-30

Plain-language summary

Dexmedetomidine provides better hemodynamic stability to the patients with hypertension undergoing laparoscopic cholecystectomy.

Who can participate

Age range

17 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Hypertensive patients of both genders of age 17 years to 70 years who are undergoing laparoscopic cholecystectomy. * ASA II and III Exclusion Criteria: * Patients with a prior history of cardiac disease like ischemic heart disease, valvular disorders, undergone previous valve replacements, infective endocarditis and rheumatic fever. * Renal diseases like acute kidney injury and chronic renal diseases. * Endocrinal diseases like pheochromocytoma, hyperthyroidism, hypothyroidism, cushing disease etc. * Pregnant and lactating females * Short thick neck with anticipated difficult intubation * Any sort of obstructive restrictive or reactive airway disease * Patient allergic to any of the study medications. * Obese patients (BMI\>35) * Narcotic addicts

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Systolic blood pressure during pneumoperitoneum

Timeframe: From baseline to the end of pneumoperitonium, an average of 2 hours

change in Diastolic blood pressure during pneumoperitoneum

Timeframe: from baseline to the end of pneumoperitoneum, an average of 2 hours

change in Mean Arterial blood pressure during pneumoperitoneum

Timeframe: from baseline to the end of pneumoperitoneum, an average of 2 hours

change in Heart Rate during pneumoperitoneum

Timeframe: from baseline to the end of pneumoperitoneum, an average of 2 hours

Trial details

NCT IDNCT04646317

SponsorDr. Ruth K.M. Pfau Civil Hospital, Karachi

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2021-03-02

Contact for this trial

Muhammad Imran, FCPS

+923342947181 dr.imranriasat@gmail.com

View on ClinicalTrials.gov More Hypertension trials

Who can participate

Age range

17 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Systolic blood pressure during pneumoperitoneum

Timeframe: From baseline to the end of pneumoperitonium, an average of 2 hours

change in Diastolic blood pressure during pneumoperitoneum

Timeframe: from baseline to the end of pneumoperitoneum, an average of 2 hours

change in Mean Arterial blood pressure during pneumoperitoneum

Timeframe: from baseline to the end of pneumoperitoneum, an average of 2 hours

change in Heart Rate during pneumoperitoneum

Timeframe: from baseline to the end of pneumoperitoneum, an average of 2 hours