This study aims to define the prevalence and potential pathophysiologic mechanisms underlying relative adrenal insufficiency (RAI) in outpatients with decompensated cirrhosis. Patients will be followed prospectively for up to two years to determine incidence of RAI, whether RAI represents a permanent or dynamic physiologic state in cirrhosis, and to determine whether RAI in this setting is associated with important clinical outcomes.
Age range
18 Years – 100 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
RAI prevalence
Timeframe: 1 year
Baseline Cholesterol Esterification Percentage
Timeframe: baseline
6 month Cholesterol Esterification Percentage
Timeframe: 6 months
12 month Cholesterol Esterification Percentage
Timeframe: 12 months
18 month Cholesterol Esterification Percentage
Timeframe: 18 months
24 month Cholesterol Esterification Percentage
Timeframe: 24 months
Baseline 17-OH Progesterone Level
Timeframe: baseline
6 month 17-OH Progesterone Level
Timeframe: 6 month
12 month 17-OH Progesterone Level
Timeframe: 12 months
18 month 17-OH Progesterone Level
Timeframe: 18 months
24 month 17-OH Progesterone Level
Timeframe: 24 months
Baseline ACTH level
Timeframe: baseline
6 month ACTH level
Timeframe: 6 months
12 month ACTH level
Timeframe: 12 months
18 month ACTH level
Timeframe: 18 months
24 month ACTH level
Timeframe: 24 months
Baseline IL-1 Level
Timeframe: baseline
6 month IL-1 Level
Timeframe: 6 months
12 month IL-1 Level
Timeframe: 12 months
18 month IL-1 Level
Timeframe: 18 months
24 month IL-1 Level
Timeframe: 24 months
Baseline Plasma Renin Activity
Timeframe: baseline
6 month Plasma Renin Activity
Timeframe: 6 month
12 month Plasma Renin Activity
Timeframe: 12 month
18 month Plasma Renin Activity
Timeframe: 18 month
24 month Plasma Renin Activity
Timeframe: 24 month
Baseline serum normetanephrine level
Timeframe: baseline
6 month serum normetanephrine level
Timeframe: 6 month
12 month serum normetanephrine level
Timeframe: 12 month
18 month serum normetanephrine level
Timeframe: 18 month
24 month serum normetanephrine level
Timeframe: 24 month
Baseline 11-deoxycortisol level
Timeframe: baseline
6 month 11-deoxycortisol level
Timeframe: 6 months
12 month 11-deoxycortisol level
Timeframe: 12 months
18 month 11-deoxycortisol level
Timeframe: 18 months
24 month 11-deoxycortisol level
Timeframe: 24 months
Baseline HDL level
Timeframe: baseline
6 month HDL level
Timeframe: 6 months
12 month HDL level
Timeframe: 12 months
18 month HDL level
Timeframe: 18 months
24 month HDL level
Timeframe: 24 months
Baseline IL-6 level
Timeframe: baseline
6 month IL-6 level
Timeframe: 6 months
12 month IL-6 level
Timeframe: 12 months
18 month IL-6 level
Timeframe: 18 months
24 month IL-6 level
Timeframe: 24 months
Baseline IL-10 level
Timeframe: baseline
6 month IL-10 level
Timeframe: 6 months
12 month IL-10 level
Timeframe: 12 months
18 month IL-10 level
Timeframe: 18 months
24 month IL-10 level
Timeframe: 24 months
Baseline TNFa level
Timeframe: baseline
6 month TNFa level
Timeframe: 6 months
12 month TNFa level
Timeframe: 12 months
18 month TNFa level
Timeframe: 18 months
24 month TNFa level
Timeframe: 24 months