CompletedNot Applicable

Marfan Syndrome Moderate Exercise Pilot

United States23 participantsStarted 2020-11-09

Plain-language summary

Marfan syndrome (MFS) affects multiple organ systems including the heart, bones, ligaments, and eyes, and is associated with significant risk of aortic dissection. Given limited evidence from in-vitro studies, and theoretical concerns, the majority of patients with MFS are restricted from certain physical activities. The lack of exercise and deconditioning have detrimental effects including increasing weakness, joint pain, decreased endurance, and depressive symptoms. Given the significant paucity of data currently existing on the effects of exercise in humans with MFS, and the recent, optimistic findings in rodent models, this pilot trial was established to assess the effects of moderated dynamic exercise in adolescents and young adults with MFS.

Who can participate

Age range12 Years – 21 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Must be between the ages of 12-21 * Diagnosis of Marfan Syndrome * Must not have other conditions that limit the patients ability to perform exercise Exclusion Criteria: * Patients who have undergone aortic surgery * Patients with major congenital heart disease

What they're measuring

Maximum VO2

Timeframe: 4 months

Trial details

NCT IDNCT04641325

SponsorBaylor College of Medicine

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-10-30

View on ClinicalTrials.gov More Marfan Syndrome trials