CompletedPhase 4

The Thiamine Administration After Cardiac Surgery Trial

Belgium200 participantsStarted 2020-11-20

Plain-language summary

Thiamine (Vitamin B1) is essential for cell function and as a co-factor of the enzyme Pyruvate Dehydrogenase to initiate the Krebs cycle and thus the aerobic metabolism of glucose. We hypothesize that thiamine supplementation improves the clearance of lactate in the first 24 hours after cardiac surgery with extracorporeal circulation in patients with high lactate concentration.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients scheduled for elective cardiac surgery with extra-corporeal circulation in the CHU de Charleroi between November 2020 and December 2021. Written informed consent will be obtained from each patient/ family member participating in the study. Exclusion Criteria: * Patients already supplemented with vitamins * Patients with an allergy to thiamine * Patients who are priorly treated with linezolide, antiretrovirals and/or metformin treatment within 48 hours preoperatively * Patients with mitochondrial disorders * Patients with Child Pugh C cirrhosis * Patients with a history of epilepsy with tonic-clonic movements postoperatively. * Pregnant patients

What they're measuring

Lactate

Timeframe: 24 hours

Trial details

NCT IDNCT04641104

SponsorSarah Saxena

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-10-03

View on ClinicalTrials.gov More Lactate Blood Increase trials