Stopped: Difficulties in recruitment of participants and end of funding
Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated with a high risk of psychiatric disorders, including schizophrenia spectrum disorders. This population is characterized by a particular neurocognitive profile and atypical brain development. Risperidone is a second-generation antipsychotic, inhibitor of dopaminergic receptors. Used in the treatment of psychosis, risperidone is frequently prescribed in 22q11DS, for example to treat a psychotic episode. Research on an animal model of 22q11DS (LgDel+/- mice) shows that administering an antipsychotic for 12 days during a critical period of brain development (adolescence) prevents deleterious neuronal changes and improves behavioral performance in mice. The aim of this study is therefore to replicate the results found in mice and to identify a long-term neuroprotective effect. This study is inspired on the one hand by the families who share with us the difficulties of individuals affected by 22q11DS on a daily basis, but also by the encouraging results of studies conducted on mice.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Conners' Continuous performance test, third edition (CPT-3)
Timeframe: CPT-3 pre-treatment
Conners' Continuous performance test, third edition (CPT-3)
Timeframe: CPT-3 One week after treatment
Conners' Continuous performance test, third edition (CPT-3)
Timeframe: CPT-3 six month after treatment
Stroop Task
Timeframe: Stroop inhibition ratio pre-treatment
Stroop Task
Timeframe: Stroop inhibition ratio one week after treatment
Stroop Task
Timeframe: Stroop inhibition ratio six month after treatment
Letter-number sequencing
Timeframe: Letter-number Sequencing pre-treatment
Letter-number sequencing
Timeframe: Letter-number Sequencing one week after treatment
Letter-number sequencing
Timeframe: Letter-number Sequencing six month after treatment
Color Trails test (CTT)
Timeframe: CTT flexibility ratio pre-treatment
Color Trails test (CTT)
Timeframe: CTT flexibility ratio one week after treatment
Color Trails test (CTT)
Timeframe: CTT flexibility ratio six month after treatment
Cambridge Neuropsychological Test Automated Battery (CANTAB)
Timeframe: CANTAB pre-treatment
Cambridge Neuropsychological Test Automated Battery (CANTAB)
Timeframe: CANTAB one week after treatment
Cambridge Neuropsychological Test Automated Battery (CANTAB)
Timeframe: CANTAB six month after treatment
15 signs & 15 words
Timeframe: 15 signs & 15 words pre-treatment
15 signs & 15 words
Timeframe: 15 signs & 15 words on week after treatment
15 signs & 15 words
Timeframe: 15 signs & 15 words six month after treatment
Magnetic Resonance Imaging (MRI) T1-weighted
Timeframe: MRI T1-weighted pre-treatment
Magnetic Resonance Imaging (MRI) T1-weighted
Timeframe: MRI T1-weighted one week after treatment
Magnetic Resonance Imaging (MRI) T1-weighted
Timeframe: MRI T1-weighted six month after treatment
MRI Spectroscopy
Timeframe: MRI Spectroscopy pre-treatment
MRI Spectroscopy
Timeframe: MRI Spectroscopy one week after treatment
MRI Spectroscopy
Timeframe: MRI Spectroscopy six month after treatment
MRI Resting State
Timeframe: MRI resting state pre-treatment
MRI Resting State
Timeframe: MRI resting state one week after treatment
MRI Resting State
Timeframe: MRI resting state six month after treatment
MRI Diffusion weighted images
Timeframe: MRI DSI pre-treatment
MRI Diffusion weighted images
Timeframe: MRI DSI one week after treatment
MRI Diffusion weighted images
Timeframe: MRI DSI six month after treatment
Electroencephalography (EEG) resting state
Timeframe: EEG resting state pre-treatment
Electroencephalography (EEG) resting state
Timeframe: EEG resting state one week after treatment
Electroencephalography (EEG) resting state
Timeframe: EEG resting state six month after treatment
EEG auditory
Timeframe: EEG Auditory pre-treatment
EEG auditory
Timeframe: EEG Auditory one week after treatment
EEG auditory
Timeframe: EEG Auditory six month after treatment
EEG visual
Timeframe: EEG Visual pre-treatment
EEG visual
Timeframe: EEG Visual one week after treatment
EEG visual
Timeframe: EEG Visual six month after treatment