Circadian Misalignment in Inflammatory Bowel Disease

Inclusion Criteria: * Age of Diagnosis is \< 40 years * Documented biopsy proven Crohn's Disease or Ulcerative Colitis * Willing to sign study consent form * At starting and during the study subject is free of prescription and over the counter medication that can affect melatonin over the past month: over the counter melatonin formulation, NSAID, alpha blocker, beta blocker, calcium channel blocker, benzodiazepine, hypnotic, barbiturate, antiepileptic, antidepressant, antipsychotic, metoclopramide Exclusion Criteria: * Active IBD flare (HBI≥5) * Use of prednisone in the past 4 weeks * Other forms of colitis, such as indeterminate colitis * Moderate/severe depression or suicidal thoughts * Restless leg syndrome * Sleep apnea * Surgical history of ileostomy or colectomy with ileal pouch * Antibiotic use within the last 14 days prior to stool collection * Active or recent infection in the last 14 days prior to stool collection * Abnormal bleeding parameters (i.e., prolonged INR), history of easy bruising or bleeding (except rectal bleeding during flare-ups) * Psychiatric disorder (diagnosis reported or EMR) * Use of anticoagulants and anti-platelet drugs * Documented chronic disease (history or current) such as diabetes, lung, heart, eye, autoimmune, seizures, kidney (creatinine \>1.2 mg/dL in last 12 months),or liver (AST/ALT \>1.5x ULN in last 12 months) * Night shift work (3 or more nights/week) or more than 2 time zones crossed in past 4 weeks * Any children \<2 years old…