The primary goal of this proposal is to collect motor and functional outcomes specific to FSHD over time. By collecting measures specific to FSHD, this will help ensure the best level of clinical care is being provided. Also, the hope is to speed up drug development by gaining a better understanding of how having FSHD impacts motor function and other health outcomes (i.e. breathing, wheelchair use, etc.) and how big a change in motor function would be clinically meaningful to those with FSHD. Motor Outcomes to Validate Evaluations in FSHD (MOVE FSHD) will have approximately 450 FSHD participants followed for a minimum of 3 years. A subset of MOVE FSHD participants, approximately 200, will participate in the MOVE+ sub-study which includes whole body MRI and reachable workspace, as well as optional muscle biopsy and wearable device (US participants only).
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
10m walk/run
Timeframe: Baseline - 5 years
Shoulder and Arm Range of Motion
Timeframe: Baseline - 5 years
Shoulder and Arm Function
Timeframe: Baseline - 5 years
Spirometry (FVC, FEV1, PCF)
Timeframe: Baseline - 5 years