Plasma Endostatin Predicts Outcome of Septic AKI

Inclusion Criteria: * Patients with sepsis defined According to Surviving Sepsis Campaign 2016 sepsis: Suspected or documented infection in addition to increase in SOFA score 2 points or more from the baseline108. * The patients will be followed for development of acute kidney injury (AKI) defined according to criteria established by Kidney Disease Improving Global Outcome guidelines (KDIGO) 20129 which includes any of the following criteria: * Increase in serum creatinine by \> 0.3 mg/dl within 48 hours; or * Increase in serum creatinine to \> 1.5 times baseline, which is Known or presumed to have occurred within the prior 7 days; or * Urine volume \< 0.5 ml/kg/h for 6 hours. Exclusion Criteria: * Critically ill patients with known history of CKD. * Patients on RRT ( intermittent or continuous) * Post renal AKI. * Not known history of nephrotoxic drug intake. * Patient with contrast induced nephropathy * Patients with cardiogenic shock who developed AKI.