CompletedNot Applicable

PRotEin Provision in Critical IllneSs

Belgium935 participantsStarted 2020-11-19

Plain-language summary

Rapid skeletal muscle wasting during critical illness had a detrimental impact on both short and long term outcomes following ICU admission. Increased dietary protein delivery might attenuate skeletal muscle wasting and its subsequent effects on post-ICU function. The investigators will conduct a 935 patient, randomised controlled, quadruple blinded parallel group trial to determine whether enteral nutrition with increased protein content in mechanically ventilated, critically ill patients is able to improve functional recovery.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult (18 years or above) patient admitted to the ICU * Unplanned ICU admission * Invasive mechanical ventilation initiated \<24 hours of ICU admission * Expected ICU stay on ventilator support of 3 days or more Exclusion Criteria: * Contraindication for enteral nutrition * Moribund or expected withholding of treatment * Kidney failure AND 'no-dialysis'-code on admission * Hepatic encephalopathy.(West Haven grade 3 or 4) * Body-mass index \< 18 kg/m2

What they're measuring

Health Related Quality of Life (HRQL)

Timeframe: Day 0, Day 30, 90 and 180 after index ICU admission.

Trial details

NCT IDNCT04633421

SponsorMaastricht University Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-10-03

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