TerminatedNot Applicable

Early Versus Delayed Intubation of Patients With COVID-19

Stopped: Insufficient rate of recruitment

Greece2 participantsStarted 2020-11-18

Plain-language summary

Although management of acute hypoxemic respiratory failure associated with coronavirus disease 2019 (COVID-19) often includes mechanical ventilation, the optimal timing of initiation of invasive mechanical ventilation remains unknown. We hypothesise that a randomized controlled trial comparing early intubation as opposed to delayed intubation among patients with COVID-19 suffering from severe acute hypoxemic respiratory failure is feasible.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Adult patients with confirmed COVID-19 and severe acute hypoxemic respiratory failure Exclusion Criteria: * Postoperative acute respiratory failure (within one week from surgery) * After cardiac arrest * Chronic hypoxemic respiratory failure * Hypercapnic respiratory failure * No full code * Lack of equipoise of the clinical team * Lack of informed consent

What they're measuring

Time from onset of severe acute hypoxemic respiratory failure to intubation

Timeframe: 28 days

Trial details

NCT IDNCT04632043

SponsorEvangelismos Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-03-15

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