RecruitingNot Applicable

Causes and Outcomes of Febrile Illness in Health Facilities in Rural South and Southeast Asia

Bangladesh, Laos, Thailand7,200 participantsStarted 2022-06-21

Plain-language summary

This prospective multi-site observational study aims to describe causes and clinical outcomes of acute febrile illness as well as host biomarkers in patients aged \>28 days residing in rural areas in Laos, Myanmar, Thailand, the Thai-Myanmar border region, and Bangladesh and presenting with acute febrile illnesses (≤ 14 days duration) to participating health facilities. This study is funded by the UK Wellcome Trust. The grant reference number is 215604/Z/19/Z

Who can participate

Age range29 Days

SexALL

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Inclusion criteria

✓. The patient and/or where relevant their parent/guardian/caretaker is willing and able to give informed consent /assent for participation in the study;
✓. Aged \> 28 days (day of birth = Day 1);
✓. Axillary temperature at presentation (≥ 37.5°C (99.5°F) OR \< 35.5°C (95.9°F)) and no more likely cause than sepsis for hypothermia OR History of fever in the 24 hours prior to presentation;
✓. Onset of illness ≤ 14 days

Exclusion criteria

✕. Accident or trauma is the cause for the patient's presentation;
✕. Presentation ≤ 3 days after routine immunisations
✕. Is currently under follow-up or has been afebrile for less than 72 hours after completion of a follow-up period.
✕. The treating healthcare worker's decision is to send the patient home following initial assessment.

What they're measuring

Prevalence of pathogens

Timeframe: Samples collected over approximately 1 month

Trial details

NCT IDNCT04629053

SponsorUniversity of Oxford

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-01

Contact for this trial

Yoel Lubell, Prof.

+66-857201350 yoel@tropmedres.ac

View on ClinicalTrials.gov More Acute Febrile Illness trials