CompletedNot Applicable

Magnesium Oral Supplementation for Acute Non-specific Low Back Pain

Turkey (Türkiye)240 participantsStarted 2018-06-10

Plain-language summary

Acute non-specific low back pain (LBP) is one of the most common complaints at the emergency department. It is more prevalent in countries with high-income economies, where 60-80% of the population report back pain at some point in their life. Numerous medication options are available for acute LBP relief such as non-steroid anti-inflammatory drugs (NSAIDs), myorelaxant drugs, opioids, and benzodiazepines. Magnesium is a physiological voltage-dependent blocker of N-methyl-D-aspartate NMDA)-coupled channels that can influence inflammatory pain and neuropathic pain through several different mechanisms. In this study the investigators aimed to investigate the effect of magnesium oral supplementation for acute low back pain.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients aged\>18 years old, * initiation of acute low back pain in the 10 days prior to study entry and functionally impairing low back pain, which we defined as a score of \> 5 on the Roland-Morris Disability Questionnaire (RMDQ). Exclusion Criteria: * aged\>65 years old, * history of trauma, * radicular pain, which we defined as pain radiating below the gluteal folds, * history of vertebral tumor or metastasis, * patients who were pregnant or lactating, * unavailable for follow-up, * with allergy or contraindication to the investigational medications, * chronic analgesic use, * autoimmune diseases or inflammatory rheumatic disorders, * cardiopulmonary restrictions, * severe kidney or liver function disorders and prior surgery on the lumbar spine.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Changed of Baseline Roland-Morris Disability Questionnaire score at 10 days

Timeframe: Baseline, at 4th and 10th days

Changed of Baseline VAS score at 10 days

Timeframe: Baseline, at 4th and 10th days

Trial details

NCT IDNCT04626063

SponsorIstanbul University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-03-15

View on ClinicalTrials.gov More Low Back Pain trials