Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas

Inclusion Criteria: * Historical grade II and III gliomas IDH wildtype gliomas by including; diffuse astrocytoma, anaplastic astrocytoma, oligodendroglioma, anaplastic oligodendroglioma, oligoastrocytoma, anaplastic oligoastrocytoma * IDH wildtype gliomas (molecularly defined high grade glioma or molecularly defined glioblastoma \[GBM\]) * History \& physical exam, and Karnofsky performance status (KFS) of \>= 70 within 30 days prior to enrollment * Post-operative magnetic resonance imaging (MRI) with contrast is mandatory and necessary for radiation therapy (RT) planning * Thin-slice (\< 1.5 mm) three-dimensional (3D) T1 pre and post contrast and axial T2/fluid-attenuated inversion recovery (FLAIR) sequences for planning purposes are highly encouraged to obtain. * Absolute neutrophil count (ANC) \>= 1,500 cells/mm\^3 (within 60 days prior to registration) * Platelets \>= 100,000 cells/mm\^3 (within 60 days prior to registration) * Hemoglobin \>= 10.0 g/dl (within 60 days prior to registration) (Note: The use of transfusion or other intervention to achieve hemoglobin \[Hgb\] \>= 10.0 g/dl is acceptable) * Bilirubin =\< 1.5 upper limit of normal (ULN) (within 60 days prior to registration) * Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =\< 3 x ULN (within 60 days prior to registration) * Blood urea nitrogen (BUN) \< 30 mg/dl (within 60 days prior to registration) * Serum creatinine \< 1.5 mg/dl (within 60 days prior to registration) Exclusion Criteria:…