Exercise induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young individuals, caused by paradoxical inspiratory adduction of laryngeal structures, and diagnosed by continuous visualization of the larynx during high intensity exercise.
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Questionnaires
Timeframe: Day 1
Pulmonary function and exercise test - Spirometry 1
Timeframe: Through study completion, on average 6 months
Pulmonary function and exercise test - Spirometry 2
Timeframe: Through study completion, on average 6 months
Pulmonary function and exercise test - Spirometry 3
Timeframe: Through study completion, on average 6 months
Continuous Laryngoscopy Exercise test (CLE-test) and scoring
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - Variables of gas exchange
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - duration of run
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - distance of run
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - oxygen consumption
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - CO2 production
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - respiratory rates.
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - heart rates.
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - Exercise tidal flow/volume loops
Timeframe: Through study completion, on average 6 months
Continuous laryngoscopy exercise (CLE) with pressure recordings
Timeframe: During Phase 3, average duration 6 months.