Exercise induced laryngeal obstruction (EILO) is a common cause of exertional breathing problems in young individuals, caused by paradoxical inspiratory adduction of laryngeal structures, and diagnosed by continuous visualization of the larynx during high intensity exercise.
Age range
12 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Questionnaires
Timeframe: Day 1
Pulmonary function and exercise test - Spirometry 1
Timeframe: Through study completion, on average 6 months
Pulmonary function and exercise test - Spirometry 2
Timeframe: Through study completion, on average 6 months
Pulmonary function and exercise test - Spirometry 3
Timeframe: Through study completion, on average 6 months
Continuous Laryngoscopy Exercise test (CLE-test) and scoring
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - Variables of gas exchange
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - duration of run
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - distance of run
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - oxygen consumption
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - CO2 production
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - respiratory rates.
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - heart rates.
Timeframe: Through study completion, on average 6 months
Cardiopulmonary exercise (CPX) data - Exercise tidal flow/volume loops
Timeframe: Through study completion, on average 6 months
Continuous laryngoscopy exercise (CLE) with pressure recordings
Timeframe: During Phase 3, average duration 6 months.