UnknownPhase 1

Airway Immune Response to Allergens (Use Lay Language Here)

United States12 participantsStarted 2021-10-28

Plain-language summary

Most asthma is allergic in origin. The purpose of this study is to better understand the airway immune response to inhaled allergens in order to identify factors that promote asthma.

Who can participate

Age range

18 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Participant must be able to understand and provide informed consent.
. Age between 18 and 50 years.
. Clinical history of at least one of the following reactions to cat dander or dust mite:
. Allergic rhinitis, with one or more of nasal congestion, sneezing, runny nose or post- nasal drainage,
. Allergic conjunctivitis, with one or more of ocular itching, tearing or swelling, or
. Urticarial reactions to contact with cats.
. Positive allergen prick test to the allergen causing clinical symptoms. A positive skin prick test is defined as a wheal sum 3 mm in diameter greater than diluent control.
. Negative urine pregnancy test at all visits for female participants of reproductive potential.

Exclusion criteria

. Inability or unwillingness of a participant to give written informed consent or comply with study protocol.
. Quantitative skin prick titration with a positive reaction to an allergen concentration of 0.056 bioequivalent allergy units (BAU) or allergy units (AU) per ml.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Dendritic cell number and phenotype

Timeframe: 18 months

Dendritic cell function

Timeframe: 18 months

Immune composition of the airway

Timeframe: 18 months

Mediators of organized airway immune tissue formation

Timeframe: 18 months

Organized airway immune tissue

Timeframe: 18 months

Trial details

NCT IDNCT04619017

SponsorJOSALYN CHO

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-04-08

View on ClinicalTrials.gov More Allergic Asthma trials

Who can participate

Age range

18 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Participant must be able to understand and provide informed consent.
. Age between 18 and 50 years.
. Clinical history of at least one of the following reactions to cat dander or dust mite:
. Allergic rhinitis, with one or more of nasal congestion, sneezing, runny nose or post- nasal drainage,
. Allergic conjunctivitis, with one or more of ocular itching, tearing or swelling, or
. Urticarial reactions to contact with cats.
. Positive allergen prick test to the allergen causing clinical symptoms. A positive skin prick test is defined as a wheal sum 3 mm in diameter greater than diluent control.
. Negative urine pregnancy test at all visits for female participants of reproductive potential.

Exclusion criteria

. Inability or unwillingness of a participant to give written informed consent or comply with study protocol.
. Quantitative skin prick titration with a positive reaction to an allergen concentration of 0.056 bioequivalent allergy units (BAU) or allergy units (AU) per ml.