Effect of Photodynamic Therapy on Skin Microbiome. Single Center Study (PHOMIC-II)

Inclusion Criteria: * Healthy male and female participants ≥ 18 years who * volunteer for the pilot study in which a routine photodynamic treatment in the Department of Dermatology will be applied and effect of skin colonization will be analyzed, and * an informed consent is signed by the participant (after information about the project). Exclusion Criteria: * Pregnant and lacting women * Participants with inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc., * Participants taking antibiotics in the 14 days prior to PDT or until follow-up at 21 days * Participants who received oral retinoid therapy within the last 6 months * Participants who received anti-inflammatory agents as NSAR within the 14 days prior and after the PDT * Participants taking any photosensitizing drugs within 4 weeks prior to PDT * Participants who had a history of photosensitivity disorder * Fitzpatrick's skin phototype V-VI