CompletedNot Applicable

Evaluation of Small Vessel Disease by 3D-rotational Angiography

Hong Kong24 participantsStarted 2020-11-05

Plain-language summary

This study is aimed to elucidate the factors affecting the remodeling process of arteriolosclerosis under current practice recommendations. Such knowledge may improve the understanding of cerebral small vessel disease (cSVD) mechanism, define pharmacological therapy and suggest treatment target.

Who can participate

Age range30 Years – 85 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Patient is Chinese ONLY
✓. Patient is 30 to 85 years of age, inclusive.
✓. Patients who have an acute lacunar infarct in diffusion-weighted MRI compatible with small vessel disease in territories supplied by the lateral lenticulostriate arteries without relevant intracranial atherosclerotic stenosis ≥60%.
✓. Patient who has no contra-indication for the proposed imaging tests.
✓. Patient who understands the purpose and requirements of the study, and has an informed consent.
✓. Patient who has Modified Functional Ambulation Classification 4 or above.

Exclusion criteria

✕. Stroke etiology uncertain or unrelated to small vessel disease, such as cardioembolism, Moyamoya disease, ICAD or primary angiitis of CNS.
✕. Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets \<100 x 109/L), coagulopathy (INR \>1.5).
✕. A medical condition that would not allow the patient to adhere to the protocol or complete the study.
✕. Patients with severe renal impairment.
✕. Patients who are taking warfarin and non-vitamin K antagonist oral anticoagulants would also be excluded.

What they're measuring

Morphological change

Timeframe: one year after recruitment

Trial details

NCT IDNCT04611906

SponsorChinese University of Hong Kong

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06-30

View on ClinicalTrials.gov More Stroke, Acute trials