CompletedNot Applicable

Rotational Thromboelastometry Versus DIC Score in Sepsis

Germany100 participantsStarted 2020-11-02

Plain-language summary

Sepsis results in activation of the coagulation system, which is commonly described as disseminated intravascular coagulation (DIC). The DIC score, which is commonly used to define this syndrome, does not allow to delineate between hypercoagulation and hypocoagulation. The aim of this prospective observational study is to evaluate data from automated rotational thromboelastometry and compare These with the DIC score regarding intensive care unit outcome.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Sepsis, defined according to the Sepsis-3 Definition * informed consent Exclusion Criteria: * age \<18 years * pregnancy and lactation * known coagulation disorder prior to Admission for sepsis * known cirrhosis of the liver * known active malignancy * surgical procedure during the last 4 weeks * refusal to participate in the study

What they're measuring

Correlation between the clotting time, clot formation time, maximum clot firmness and lysis index at 30 minutes from FIBTEM, INTEM, EXTEM and APTEM measurements of the ROTEM assay with an overt DIC on the day of sepsis diagnosis regarding ICU survival

Timeframe: through study completion, up to an average of 7 days

Trial details

NCT IDNCT04610853

SponsorUniversity of Leipzig

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-03-31

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