The aim of the project is to identify new risk indicators of PFO. The evaluation of the R-L shunt is based on the newly developed precise measurement technique. Moreover, this measurement of R-L shunt is feasible in a case when R-L shunt is present only intermittently. Multicentric study with 150 patients.
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Quantification of R-L shunt namely
Timeframe: Up to 24 weeks
Transesophageal Echocardiography examination before Patent foramen ovale closure
Timeframe: Up to 24 weeks (Prior subject's Patent foramen ovale closure)
Evaluation of the severity of Right-Left shunt and comparison with atrial septal morphology
Timeframe: Up to 24 weeks
Spiroergometric examination with the measurement of VO2max
Timeframe: 6 months after Patent foramen ovale closure by means of a Patent foramen ovale occluder
Spiroergometric examination with the measurement of SpO2
Timeframe: 6 months after Patent foramen ovale closure by means of a Patent foramen ovale occluder
Transesophageal Echocardiography routine examination after 6 months after Patent foramen ovale closure
Timeframe: Up to 24 weeks
Influence of significant R-L shunt on exercise tolerance and quality of life of the patient
Timeframe: Up to 24 weeks