CompletedNot Applicable

A Retrospective Analysis of the Diagnostic Performance of 11C-choline PET/CT in Primary Hyperparathyroidism

36 participantsStarted 2015-01-01

Plain-language summary

The leading cause of primary hyperparathyroidism (pHPT) is a solitary adenoma (89%). The treatment of pHPT is generally surgical removal of the overactive parathyroid gland(s). Since a solitary adenoma is the predominant cause, parathyroid surgery is preferably performed through a minimally invasive parathyroidectomy (MIP) in which only the suspected adenoma causing the pHPT is resected in a focused manner. To facilitate the performance of a MIP, accurate preoperative imaging is pivotal. This study aimed to analyze the diagnostic performance of 11C-choline PET/CT after prior negative or discordant first-line imaging in patients with pHPT undergoing parathyroid surgery with an optimized imaging protocol.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: Patients eligible for inclusion were ≥18 years old, diagnosed with biochemically confirmed pHPT, underwent a MIBI-SPECT/CT and/or cUS with negative or discordant results, and underwent a 11C-choline PET/CT followed by parathyroidectomy. Exclusion Criteria: Patients were excluded if they were known to have a germline mutation predisposing for familial hypocalciuric hypercalcemia (FHH).

What they're measuring

Sensitivity of 11C-choline PET/CT

Timeframe: Until 6 months after parathyroid surgery

Positive predictive value of 11C-choline PET/CT

Timeframe: Until 6 months after parathyroid surgery

Accuracy of 11C-choline PET/CT

Timeframe: Until 6 months after parathyroid surgery

Trial details

NCT IDNCT04608253

SponsorUniversity Medical Center Groningen

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-12-31

View on ClinicalTrials.gov More Primary Hyperparathyroidism trials