Efficacy of Mouthwash in Reducing Salivary Carriage of COVID-19 (NCT04603794) | Clinical Trial Compass
UnknownPhase 4
Efficacy of Mouthwash in Reducing Salivary Carriage of COVID-19
United States60 participantsStarted 2020-10-01
Plain-language summary
Researchers know that the virus that causes COVID-19 has been found in the saliva (spit) of individuals who exhibit signs of the disease. Investigators would like to test the ability of three mouthwashes to reduce the levels of this virus in participants' mouths. Investigators will ask participants to use a liquid to swish around in the mouth for 30 seconds and spit it into a collection cup. Investigators will also collect spit from participants before and after participants use the mouthwash. Although participants will have no direct benefits from the study, investigators will gain a wealth of information that would benefit patients who are at risk for COVID-19.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. adults age 18-80 admitted to The Ohio State University Medical Center,
. diagnosis of COVID-19 confirmed by Polymerase Chain Reaction (PCR),
. salivary carriage of COVID-19 virus
. ability to perform mouthwash rinses and to expectorate.
Exclusion criteria
. allergy to any study mouth rinse,
. active uncontrolled thyroid disease,
. pregnancy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
real time reverse transcriptase quantitative PCR
Timeframe: 3 measurements of changes from times 0 minutes. vs:15 minutes, and vs: 45 minutes during a single session
2
ct values
Timeframe: 3 measurements of changes from times 0 minutes.vs:15 minutes, and vs:45 minutes during a single session