Testosterone Treatment for Erectile Dysfunction and Multiple Sclerosis

Inclusion Criteria: * Males, age 18 years and older, with a definite diagnosis of multiple sclerosis. * Low testosterone (\<300 ng/dl) on two successive blood draws before 9:00 am * Not in an intercurrent relapse. * Sexually active. * Have subjective complaints about erectile function and libido. * Must be willing and able to get labs drawn, complete questionnaires (BDI, MFIS, MSNQ, SDMT, MSQOL, ADAM, AUASS, SHIM, MSHQ, ICIQ, UDI, IIQ, MPQ) and commit to site visits schedule. Exclusion Criteria: * Males unable to fulfill the above criteria and all female patients. * Males who have been on sex hormone treatment including androgens, estrogens, or anti-estrogens for hypogonadism or other medical condition during the 12 months prior to study. * Males who have taken dehydroepiandrosterone (DHEA) during the 3 months prior to study. * Patients who are taking anticoagulants or have thrombosis, serious cardiac, pulmonary, renal, gastrointestinal, hepatic, immunologic, infectious, neoplastic (with particular focus on patients with known or suspected estrogen or testosterone-dependent tumors), urologic disease especially prostatic hypertrophy/nodules and testicular mass, or insulin-dependent diabetes. * Patients with an abnormal prostate as evidenced by known history of prostatic disease, symptoms suggestive of prostatic disease or elevated levels of prostatic specific antigen (PSA 4 ng/ml or higher) measured within the last 12 months. * Patients with history or complaint of testicul…