Integrated Boost to the Dominant Intraprostatic Nodule Based on Ga-68 PSMA PET/MR Study of SBRT With Prostate Cancer

Inclusion Criteria: * Histologically confirmed adenocarcinoma of the prostate * tumor clinical stage cT1-3N0M0 according to AJCC TNM 2017 * Without any treatment of prostate cancer including radiotherapy, ADT, chemotherapy, focal treatment, etc. * With the examination of Ga-68 PSMA PET/MR * International Prostate Symptom Score(IPSS）\<15 (alpha blockers allowed), without severe urethral obstruction symptoms * ECOG performance status 0-2 * Written informed consent according to ICH/GCP regulations before registration and prior to any trial specific procedures Exclusion Criteria: * Prior pelvic RT * A tumor located at less than 3 mm from the urethra or rectum when measured at the MRI * Tumor clinical stage cT4, with metastases including bone, lymph nodes or organ metastasis * Histologically confirmed neuroendocrine tumor or small cell carcinoma of the prostate * Severe or active co-morbidity likely to impact on the advisability of SBRT like severe liver or kidney dysfunction, etc. * Patients with other malignancies, or acute or other severe infections, with ulcerative colitis, inflammatory bowel disease, etc. * Patients who have participated in other clinical trials for less than three months * Patients have acute prostatitis or chronic prostatitis with urinary symptoms * Urine routine indicates obvious urinary system infection and no significant improvement after anti-infective treatment, or conversion to recurrent urinary system infection * Unsuitable to participate in this …