Pharmacological and Behavioral Treatment After Bariatric Surgery: Acute (Stage 1)

Inclusion Criteria: * Be in the age range ≥18 years of age and ≤70 years of age. * Have a BMI ≥30 (or BMI ≥27 with a medical comorbidity) and ≤50 * Have had laparoscopic Roux-en-Y gastric bypass or sleeve gastrectomy * Approximately six months post-surgery * Experience regular loss-of-control eating (defined as at least once weekly over the past 28 days) * Be an otherwise healthy subject without uncontrolled medical problems, as determined by the study physician and medical co-investigators (physical examination, laboratory studies). * Read, comprehend, and write English at a sufficient level to complete study-related materials. * Provide a signed and dated written informed consent prior to study participation. Be available for participation in the study for up to 19 months (7-month treatment plus 12-month follow up). Exclusion Criteria: * Has a predisposition to seizures (e.g., subject with a history or evidence of seizure disorder, febrile seizures during childhood, brain tumor, cerebrovascular disease, or significant head trauma; has a family history of idiopathic seizure disorder or is currently being treated with medications or treatment regimens that lower seizure threshold). * Has a history of anorexia nervosa or history of bulimia nervosa. * Is currently taking a medication that is a contraindication to NB medication (e.g., MAOI, opiates). * Is currently using other medications for weight loss. * Has a history of allergy or sensitivity to bupropion or naltrexone. …