By InvitationNot Applicable

Corneal Biomechanical Analysis Using Brillouin Microscopy

United States220 participantsStarted 2021-06-01

Plain-language summary

The objective of this study is to measure the Brillouin biomechanical properties in keratoconic corneas and characterize biomechanical alterations that occur after corneal procedures that inherently strengthen or weaken the cornea by evaluating the change in Brillouin metrics before and after treatments.

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients aged 18-60 with keratoconus * patients aged 18-60 with normal corneas, * patients aged 18-60 undergoing refractive surgery (LASIK, PRK, SMILE) * patients aged 18-60 with keratoconus undergoing CXL Exclusion Criteria: * outside age range * history of previous ocular surgeries * unable to cooperate for the Brillouin microscopic examination * unable to provide informed consent

What they're measuring

Change in Brillouin Metrics

Timeframe: Difference between baseline and 3 months after intervention

Trial details

NCT IDNCT04598932

SponsorThe Cleveland Clinic

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-07

View on ClinicalTrials.gov More Keratoconus trials