UnknownNot Applicable

Assessment of Lung Mechanics in COVID-19 Acute Respiratory Distress Syndrome

Switzerland25 participantsStarted 2021-03-01

Plain-language summary

This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced acute respiratory failure and thus lead to better mechanical ventilation strategies. This monocentric, observational study of critically ill COVID-19 patients in the ICU, will employ impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry as well as classic mechanical ventilation parameters to characterise the mechanical characteristics of the lung as well as the heart-lung interactions in SARS-CoV-2 induced acute respiratory failure.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * SARS-CoV-2 infection * Moderate to Severe ARDS after Berlin Classification at PEEP 5 * Admission to the Institute of Intensive Care of the University Hospital Zurich * Invasive Mechanical Ventilation * Signed Study Informed Consent or emergency procedure according to article 30 HFG Exclusion Criteria: * Pregnant or breast feeding patients * Age \<18 years * Presumed rejection of the study intervention

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Time dependent compliance change

Timeframe: Mixed Model Assessment of compliance over time until extubation (measurements every 2 days up to 90 days)

PEEP and time dependent change in dead space

Timeframe: Mixed Model Assessment of Dead Space over time until extubation (measurements every 2 days up to 90 days)

PEEP and time dependent change in shunt fraction

Timeframe: Mixed Model Assessment of shunt fraction over time until extubation (measurements every 2 days up to 90 days)

Trial details

NCT IDNCT04597853

SponsorUniversity of Zurich

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-12-31

Contact for this trial

Philipp K Buehler, MD

+41 43 25 31340 Philipp.Buehler@usz.ch

View on ClinicalTrials.gov More Covid19 trials