This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced acute respiratory failure and thus lead to better mechanical ventilation strategies. This monocentric, observational study of critically ill COVID-19 patients in the ICU, will employ impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry as well as classic mechanical ventilation parameters to characterise the mechanical characteristics of the lung as well as the heart-lung interactions in SARS-CoV-2 induced acute respiratory failure.
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Time dependent compliance change
Timeframe: Mixed Model Assessment of compliance over time until extubation (measurements every 2 days up to 90 days)
PEEP and time dependent change in dead space
Timeframe: Mixed Model Assessment of Dead Space over time until extubation (measurements every 2 days up to 90 days)
PEEP and time dependent change in shunt fraction
Timeframe: Mixed Model Assessment of shunt fraction over time until extubation (measurements every 2 days up to 90 days)