CompletedNot Applicable

Lymphatic Function in Patients With Secondary Tricuspid Valve Regurgitation

Denmark18 participantsStarted 2020-09-15

Plain-language summary

The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls. The study will use t2 weighted MRI, Near-infrared fluorescence imaging, and plethysmography to examine the above-mentioned question.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Patients: Inclusion criteria: * Patients with moderate to severe tricuspid regurgitation * Age ≥18 years * Informed consent Exclusion criteria: * Reduced ejection fraction (\<50%) * Congenital heart disease * Left sided valve disease * MRI contraindications (All metal implants, cochlear implants, pacemakers etc.) * Claustrophobia * Peripheral edema * BMI\>30 * Age\<18. Controls: Inclusion criteria: * Healthy * Age ≥18 years * Age, gender and weight matched with included patients. Exclusion criteria: * Cardiovascular disease * MRI contraindications (All metal implants, cochlear implants, pacemakers etc.) * Claustrophobia * Peripheral edema * BMI\>30 * Age\<18.

What they're measuring

Thoracic duct tortuosity (centimeters/centimeters)

Timeframe: 20 minutes

Thoracic duct volume (cubic centimetres)

Timeframe: 30 minutes

Excess fluid (yes/no)

Timeframe: 40 minutes

Peripheral lymphatic velocity (centimeters/second)

Timeframe: 1 hour

Peripheral lymphatic frequency (contractions/minute)

Timeframe: 1 hour 30 minutes

Trial details

NCT IDNCT04595448

SponsorUniversity of Aarhus

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-11-15

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